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Adipose tissue is a physiologic reservoir of fatty acids, 311 when the storage capacity is exceeded, the accumulation of heterotopic lipids leads to lipotoxicity, thereby promoting low-grade inflammation and IR in the liver

Semaglutide dramatically reduces appetite, driving weight loss but increasing risk

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Side effects that indirectly cause stalls Some GLP-1 side effects do not directly cause stalls but create conditions where stalls become more likely